Carcassi A M, Concu A, Decandia M, Onnis M, Orani G P, Piras M B
Pflugers Arch. 1984 Apr;400(4):409-12. doi: 10.1007/BF00587541.
Increments in pulmonary ventilation were shown to occur in anaesthetized cats during long-lasting stimulation of a peripherally cut extensor muscle nerve at maximal intensity for group I afferent fibers. However, these increments tended to gradually adapt to a lower value when stimuli were delivered at high frequency and constant rate whereas a tendency to potentiation, up to a steady state, occurred when stimulation was intermittent. End-tidal PCO2 initially decreased with a tendency to adaptation in the case of continuous stimulation, and decreased progressively in the case of intermittent stimulation. It is concluded that the nervous mechanisms producing hyperpnoea exhibit fatigue during their constant excitation while their effects sum up during intermittent stimulation.
在对麻醉猫的外周切断伸肌神经以最大强度刺激Ⅰ类传入纤维时，发现肺通气量增加。然而，当以高频和恒定速率给予刺激时，这些增加的通气量倾向于逐渐适应较低的值，而当刺激为间歇性时，则会出现增强至稳定状态的趋势。在持续刺激的情况下，呼气末二氧化碳分压最初下降并伴有适应趋势，而在间歇性刺激的情况下则逐渐下降。得出的结论是，产生呼吸急促的神经机制在持续兴奋时会出现疲劳，而在间歇性刺激时其作用会叠加。
