Berge G N, Smeds E
Nord Vet Med. 1984 May-Jun;36(5-6):156-61.
The efficacy of ivermectin against natural infection of the mange mite Sarcoptes scabiei var canis in foxes was evaluated. The investigations consisted of two field studies and one controlled study. In experiment 1, ivermectin was given as a single subcutaneous dose at 200 micrograms/kg in six foxes. In experiment 2, was one group, consisting of five animals, administered 200 micrograms ivermectin/kg s.c. twice with an interval of 35 days. Group two, consisting of four animals, was given one subcutaneous injection of 400 micrograms ivermectin/kg. In experiment 3, ten foxes were given 1 ml 0.2% Eqvalen s.c. (i.e. 340-440 micrograms ivermectin/kg). A control group of ten animals was not medicated. Before and after treatment a clinical evaluation and skin scraping for microscopic examination was carried out in all three experiments. The results indicated that ivermectin was a good alternative in the therapy of the Sarcoptes mange in foxes by moderate mite infection. A progressive clinical improvement of the mange lesions was evident in the treated foxes. Mites were not detected in skinscraping, except in one animal in experiment 3. It was concluded that ivermectin should be administered, in an initial dose of 400 micrograms/kg and a repeated dose of 200 micrograms/kg 2-3 weeks after the first treatment.
评估了伊维菌素对狐狸疥螨自然感染的疗效。研究包括两项现场研究和一项对照研究。在实验1中，对6只狐狸以200微克/千克的剂量皮下注射一次伊维菌素。在实验2中，一组由5只动物组成，以200微克伊维菌素/千克的剂量皮下注射两次，间隔35天。第二组由4只动物组成，皮下注射一次400微克伊维菌素/千克。在实验3中，给10只狐狸皮下注射1毫升0.2%的依瓦伦（即340 - 440微克伊维菌素/千克）。一个由10只动物组成的对照组未用药。在所有三个实验中，治疗前后都进行了临床评估和皮肤刮片显微镜检查。结果表明，对于中度螨感染的狐狸疥螨病治疗，伊维菌素是一个很好的选择。治疗后的狐狸疥螨病变有明显的临床改善。除了实验3中的一只动物外，皮肤刮片中未检测到螨虫。得出的结论是，伊维菌素应以400微克/千克的初始剂量给药，首次治疗后2 - 3周重复给药200微克/千克。
