Alva-Valdes R, Wallace D H, Benz G W, Foster A G, Holste J E
Am J Vet Res. 1984 Oct;45(10):2113-4.
The efficacy of ivermectin administered by esophageal intubation in a single dose was evaluated against the mange mite Sarcoptes scabiei var suis in 24 naturally infested pigs. Six pigs were allocated to each of the 4 treatment groups. Control (group 1) pigs were given nonmedicated water, group 2 were given ivermectin at 300 micrograms/kg of body weight, group 3 were given ivermectin at 400 micrograms/kg, and group 4 were given ivermectin at 500 micrograms/kg. The pigs were examined for S scabiei before treatment and on days 7, 14, 21, and 28 after treatment. Of the 18 ivermectin-treated pigs, 10 had no live S scabiei recovered on day 7 after treatment, 16 had none on day 14, 18 had none on day 21, and 16 had none on day 28. All 6 nonmedicated control pigs had live S scabiei recovered on days 7 and 21, and 5 control pigs had mites on days 14 and 28. The single administration of ivermectin given by esophageal intubation was highly effective in reducing the number of S scabiei at all dose levels tested. The pooled ivermectin-treated groups had significantly (P less than 0.01) fewer mites than the control group on all posttreatment examination days. There were no statistically significant differences among the ivermectin dose levels.
通过食管插管单剂量给予伊维菌素对24头自然感染猪疥螨的猪进行疗效评估。将6头猪分配到4个治疗组中的每组。对照组（第1组）猪给予无药的水，第2组猪给予300微克/千克体重的伊维菌素，第3组猪给予400微克/千克的伊维菌素，第4组猪给予500微克/千克的伊维菌素。在治疗前以及治疗后第7、14、21和28天对猪进行疥螨检查。在18头接受伊维菌素治疗的猪中，10头在治疗后第7天未检出存活的疥螨，16头在第14天未检出，18头在第21天未检出，16头在第28天未检出。所有6头未用药的对照猪在第7天和第21天检出存活的疥螨，5头对照猪在第14天和第28天检出螨虫。通过食管插管单次给予伊维菌素在所有测试剂量水平下对减少疥螨数量均非常有效。在所有治疗后检查日，合并的伊维菌素治疗组的螨虫数量均显著（P<0.01）少于对照组。伊维菌素各剂量水平之间无统计学显著差异。
