Kubos K L, Moran T H, Saad K M, Robinson R G
Pharmacol Biochem Behav. 1984 Jul;21(1):163-7. doi: 10.1016/0091-3057(84)90147-3.
The role of norepinephrine depletion in the lateralized production of spontaneous hyperactivity was assessed by unilateral fronto-cortical injections of either 10 or 20 micrograms of the noradrenergic neurotoxin, DSP-4 (N-2-chlorethyl-N-ethyl-bromobenzylamine hydrochloride). Ten micrograms of DSP-4 produced significant hyperkinesis only when injected into the right hemisphere. A 20 micrograms dose produced hyperactivity when injected into either hemisphere. DSP-4 injections resulted in significant NE and ipsilateral and contralateral 5HT depletions in the frontal cortex. The 20 micrograms right hemispheric injection significantly increased both DOPAC and DA levels in the contralateral caudate in a manner unrelated to behavior. These findings, in conjunction with results from previous neurotoxin studies, support a hypothesis of greater relative sensitivity to injury of right hemispheric NE terminal fields compared with injury to left hemispheric fields as demonstrated by spontaneous hyperactivity.
通过向单侧额叶皮质注射10微克或20微克的去甲肾上腺素能神经毒素DSP-4（N-2-氯乙基-N-乙基-溴苄胺盐酸盐），评估去甲肾上腺素耗竭在自发性多动的侧化产生中的作用。仅当注入右半球时，10微克的DSP-4会产生显著的运动亢进。20微克剂量注入任一半球时都会产生多动。DSP-4注射导致额叶皮质中去甲肾上腺素以及同侧和对侧5-羟色胺显著耗竭。20微克的右半球注射以与行为无关的方式显著增加了对侧尾状核中的3,4-二羟基苯乙酸和多巴胺水平。这些发现与先前神经毒素研究的结果相结合，支持了这样一种假说，即与左半球场损伤相比，右半球去甲肾上腺素终末场对损伤的相对敏感性更高，这表现为自发性多动。
