麦角新碱可降低甲硫氨酸脑啡肽的强效类似物FK 33 - 824 [酪氨酰 - D - 丙氨酰 - 甘氨酰 - 对甲硫苯丙氨酰 - 蛋氨酸（氧代）醇] 后的催乳素释放。一项人体研究。
Methysergide decreases prolactin release after FK 33-824 [Tyr-D-Ala-Gly-MePhe-Met(o)-ol], a potent analogue of methionine enkephalin. A study in man.
作者信息
Jungkunz G, Nedopil N, Rüther E
出版信息
Psychopharmacology (Berl). 1984;83(2):210-2. doi: 10.1007/BF00429737.
PMID:6431476
Abstract
This study investigated the mechanisms which may underly the prolactin (PRL) stimulating effects of FK 33-824, a potent enkephalin analogue. FK 33-824 (1 mg) was infused in healthy volunteers before and after pretreatment with 3 mg methysergide, a serotonin receptor blocker. All subjects showed a release of PRL after FK 33-824, which was significantly diminished after pretreatment with methysergide.
摘要
本研究调查了强效脑啡肽类似物FK 33-824刺激催乳素（PRL）分泌的潜在机制。在健康志愿者中，先给予5-羟色胺受体阻滞剂麦角新碱3mg预处理，然后注入FK 33-824（1mg）。所有受试者在注入FK 33-824后均出现PRL释放，而在麦角新碱预处理后，PRL释放显著减少。
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