Rodríguez Méndez S A, Feria M, Borges R, Boada J
Rev Esp Fisiol. 1984 Mar;40(1):53-61.
The time course of respiratory parameters and blood pressure was studied in decerebrated rats (DR), decerebrated rats treated with a combination of thiopental plus urethane (DAR), and intact brain rats anesthetized with the same combination (IBAR). Moreover, the respiratory sensitivity to a stimulating dose of amphetamine was tested in the three preparations. DR exhibited a spontaneous and steady increase of ventilation which was absent in DAR. A steady increase of ventilation was also observed in IBAR, although of a lesser intensity. Amphetamine induced a clear respiratory stimulation which was decreased by the administration of anesthetics. A tendency to hypotension was seen in all animals. Therefore, the respiratory instability and the decreased pharmacological response observed in the presence of anesthetics are important factors to be considered when interpreting results obtained in this kind of preparations.
研究了去大脑大鼠（DR）、硫喷妥钠加乌拉坦联合处理的去大脑大鼠（DAR）以及用相同联合麻醉的完整脑大鼠（IBAR）的呼吸参数和血压随时间的变化过程。此外，还在这三种制备物中测试了对刺激剂量苯丙胺的呼吸敏感性。DR表现出自发性且稳定的通气增加，而DAR中不存在这种情况。在IBAR中也观察到通气稳定增加，尽管强度较小。苯丙胺引起明显的呼吸刺激，而麻醉剂给药可使其减弱。所有动物均有低血压倾向。因此，在解释这类制备物中获得的结果时，麻醉剂存在时观察到的呼吸不稳定和药理反应降低是需要考虑的重要因素。
