[Protective effect of beta-carotene and canthaxanthin against UV reactions of the skin].

Clinical experiments could demonstrate that beta-carotene and canthaxanthin (Carotinoid-N), orally applied, decreases ultraviolet sensitivity such as manifests itself by erythematous reactions. The dosage administered was 4 dragees daily (1 dragee contains 25 mg beta-carotene and 35 mg canthaxanthin) for two weeks and 2 dragees daily for another two weeks. There was no induction of melanin production observed. In vitiligo, administration of Carotinoid-N failed to induce repigmentation, but the contrast between vitiliginous white patches and the surrounding pigmented skin was markedly reduced by carotinoids deposited in the skin. In addition, sun protection was afforded. Carotinoid-N induced a photoprotecting action in patients with pronounced ultraviolet sensitivity or with polymorphic light eruptions (PLE). In some cases, however, we recommend an additional pretreatment with ultraviolet light ("ultraviolet hyposensitization"). With acne-lesions, the common sun lotions and creams should be avoided: only preparations without emulsifiers may be made use of.