Tronnier H
Z Hautkr. 1984 Jul 1;59(13):859-70.
Clinical experiments could demonstrate that beta-carotene and canthaxanthin (Carotinoid-N), orally applied, decreases ultraviolet sensitivity such as manifests itself by erythematous reactions. The dosage administered was 4 dragees daily (1 dragee contains 25 mg beta-carotene and 35 mg canthaxanthin) for two weeks and 2 dragees daily for another two weeks. There was no induction of melanin production observed. In vitiligo, administration of Carotinoid-N failed to induce repigmentation, but the contrast between vitiliginous white patches and the surrounding pigmented skin was markedly reduced by carotinoids deposited in the skin. In addition, sun protection was afforded. Carotinoid-N induced a photoprotecting action in patients with pronounced ultraviolet sensitivity or with polymorphic light eruptions (PLE). In some cases, however, we recommend an additional pretreatment with ultraviolet light ("ultraviolet hyposensitization"). With acne-lesions, the common sun lotions and creams should be avoided: only preparations without emulsifiers may be made use of.
临床试验能够证明，口服β-胡萝卜素和角黄素（类胡萝卜素-N）可降低紫外线敏感性，这种敏感性表现为红斑反应。给药剂量为每天4片糖衣丸（1片糖衣丸含25毫克β-胡萝卜素和35毫克角黄素），持续两周，之后每天2片糖衣丸，再持续两周。未观察到黑色素生成的诱导情况。在白癜风患者中，服用类胡萝卜素-N未能诱导色素再生，但沉积在皮肤中的类胡萝卜素显著降低了白癜风白色斑块与周围色素沉着皮肤之间的对比度。此外，还提供了防晒保护。类胡萝卜素-N对紫外线敏感性明显或患有多形性日光疹（PLE）的患者具有光保护作用。然而，在某些情况下，我们建议额外进行紫外线预处理（“紫外线减敏疗法”）。对于痤疮皮损，应避免使用常见的防晒乳液和面霜：只能使用不含乳化剂的制剂。
