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[T-激活素对免疫干扰素产生的影响]

[Effect of T-activin on the production of immune interferon].

作者信息

Chuchalin A G, Babushkina V A, Arion V Ia, Aspetov R D, Shaĭkhinova T B

出版信息

Biull Eksp Biol Med. 1984 Jul;98(7):76-8.

PMID:6432072
Abstract

A study was made of the effect of T-activin on the biosynthesis of immune gamma-interferon. It was shown that in 27% of patients with chronic nonspecific pulmonary diseases, production of gamma-interferon by lymphocytes was substantially reduced during exacerbation of inflammatory process in the lungs. It was discovered that T-activin was not an interferon inductor but enhanced its synthesis in patients with a low capacity of producing immune interferon even at small doses of interferon inductor. The preparation does not produce any effect on this process in normal subjects and in patients showing the normal level of gamma-interferon. Thus T-activin can be used for stimulation of interferonogenesis.

摘要

研究了T-激活素对免疫γ-干扰素生物合成的影响。结果表明,在27%的慢性非特异性肺部疾病患者中,肺部炎症过程加重时淋巴细胞产生γ-干扰素的能力显著降低。研究发现,T-激活素不是干扰素诱导剂,但即使在小剂量干扰素诱导剂的情况下,它也能增强免疫干扰素产生能力较低的患者体内干扰素的合成。该制剂对正常受试者和γ-干扰素水平正常的患者的这一过程没有任何影响。因此,T-激活素可用于刺激干扰素生成。

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