Seĭsenbaev A Sh
Ter Arkh. 1985;57(8):132-5.
A study was made of the effect of the drugs with an immunostimulant (T-activin, levamisole) and immunosuppressant (prospidin) activity on the synthesis of IgA, IgM and IgG in vitro in lymphoid cultures of 7 healthy donors, 16 patients with seropositive and 9 patients with seronegative rheumatoid arthritis (RA). It was shown that the model of the synthesis of immunoglobulins in vitro demonstrates the impairment of T-B-cell cooperation of lymphocytes in RA patients. It was establised that the effect of immunologically active drugs on the synthesis of immunoglobulins depends on the character of the drug immunotropic action and initial functional activity of the immunoregulatory T-lymphocytes. Like polyclonal mitogens, levamisole and, to a greater extent, T-activin stimulating the initially low activity of T helpers increase spontaneous synthesis of immunoglobulins in lymphoid cultures of patients with seronegative RA, whereas in seropositive RA, these drugs stimulating the initially low activity of T suppressors carrying Fc gamma-receptors inhibit this process. Prospidin inhibit the synthesis of immunoglobulins equally in both RA patterns. Indications and contraindications for administration of he immunologically active drugs on a clinical bases are discussed.
对具有免疫刺激活性（T-激活素、左旋咪唑）和免疫抑制活性（丙哌啶）的药物对7名健康供体、16名血清阳性类风湿性关节炎（RA）患者和9名血清阴性类风湿性关节炎患者的淋巴细胞培养物中IgA、IgM和IgG体外合成的影响进行了研究。结果表明，体外免疫球蛋白合成模型显示RA患者淋巴细胞的T-B细胞合作受损。已确定免疫活性药物对免疫球蛋白合成的影响取决于药物免疫趋向作用的性质和免疫调节性T淋巴细胞的初始功能活性。与多克隆有丝分裂原一样，左旋咪唑以及在更大程度上刺激初始低活性T辅助细胞的T-激活素可增加血清阴性RA患者淋巴细胞培养物中免疫球蛋白的自发合成，而在血清阳性RA中，这些刺激携带Fcγ受体的初始低活性T抑制细胞的药物会抑制这一过程。丙哌啶在两种RA模式中均同等程度地抑制免疫球蛋白的合成。讨论了基于临床应用免疫活性药物的适应证和禁忌证。
