Ingemann-Hansen T, Halkjaer-Kristensen J
Br J Sports Med. 1984 Jun;18(2):70-3. doi: 10.1136/bjsm.18.2.70.
The relationship of maximal oxygen uptake (VO2 max) with dihydrogenated ergot alkaloids was investigated in twelve young men. They were subjected to graded bicycle exercise with work loads corresponding to 75% and 120% of the load necessary to elicit VO2 max. The exercise tests were performed after intravenous administration of 2 mg dihydroergostin (DE-145) as well as after saline as control, both preparations were given double-blind. VO2 max averaged (SD) 3.36 (0.41) 1/min and no significant difference was disclosed between the DE-145 and the control situation. Normal relationships were observed between VO2 and work load, ventilation, heart rate, cardiac output, central venous pressure and acid-base data, and these relations were unaffected by DE-145 administration. Nausea was constantly seen in all subjects tested with DE-145. It is concluded, that the present dose of DE-145 has no influence on the functional capacity of the oxygen transporting system in sedentary young men.
在12名年轻男性中研究了最大摄氧量（VO2 max）与二氢麦角生物碱的关系。他们进行了分级自行车运动，运动负荷相当于诱发VO2 max所需负荷的75%和120%。在静脉注射2毫克二氢麦角隐亭（DE - 145）后以及注射生理盐水作为对照后进行运动测试，两种制剂均采用双盲给药。VO2 max平均为（标准差）3.36（0.41）升/分钟，DE - 145与对照情况之间未发现显著差异。VO2与工作负荷、通气、心率、心输出量、中心静脉压和酸碱数据之间观察到正常关系，并且这些关系不受DE - 145给药的影响。在所有接受DE - 145测试的受试者中均持续出现恶心症状。得出结论，当前剂量的DE - 145对久坐不动的年轻男性的氧运输系统功能能力没有影响。
