Hool-Zulauf B, Stürmer E
Arzneimittelforschung. 1977;27(12):2323-5.
The effect of two recently synthetized dihydrogenated ergot peptide alkaloids has been investigated on the rabbit uterus in situ. The method is described in detail. 6-Nor-6-isopropyl-9,10-dihydro-2'beta-methyl-5'alpha-benzyl-ergopeptine (DZ 26-474) and 6-nor-6-idopropyl-9,10-dihydro2'8-methyl-5'alpha-isopropyl-ergopeptine (28-377) possess 33% and 59%, respectively, of the oxytocic activity of methylergometrine (Methergine). The uterotonic effect of DZ 26-474 and 28-377 can be completely abolished by pretreatment with alpha-adrenoceptor blocking drugs, indicating involvement of alpha-adrenoceptors. Results obtained are discussed in relation to the concept that dihydrogenated ergot peptide alkaloids usually inhibit spontaneous contractions of the uterus and contractions induced by methylergometrine.
研究了两种最近合成的二氢麦角肽生物碱对家兔在位子宫的作用。详细描述了该方法。6-去甲-6-异丙基-9,10-二氢-2'β-甲基-5'α-苄基麦角肽（DZ 26-474）和6-去甲-6-异丙基-9,10-二氢-2'β-甲基-5'α-异丙基麦角肽（28-377）的催产活性分别为甲基麦角新碱（麦角新碱）的33%和59%。用α-肾上腺素受体阻断药预处理可完全消除DZ 26-474和28-377的子宫收缩作用，表明α-肾上腺素受体参与其中。结合二氢麦角肽生物碱通常抑制子宫自发收缩和甲基麦角新碱诱导的收缩这一概念对所得结果进行了讨论。
