Bakiri F, Benmiloud M
Br Med J (Clin Res Ed). 1984 Sep 8;289(6445):579-80. doi: 10.1136/bmj.289.6445.579.
Twenty patients with postpartum hypopituitarism underwent a dehydration test followed by the administration of synthetic arginine-vasopressin (DDAVP; desmopressin). Panhypopituitarism was confirmed by hormonal assays in the basal state and after stimulation with combined luteinising hormone releasing hormone-thyrotrophin releasing hormone-insulin. All the patients were given replacement therapy with hydrocortisone and thyroid hormones. Results were compared with those in 12 normal women. Urinary concentrating ability was diminished in the patients as compared with the controls (maximum urine osmolality 688 (SEM 23) mmol (mosmol)/kg in the patients v 967 (SEM 29) mmol/kg in the controls). Also the change in urine osmolality after administration of desmopressin was greater in the patients (+9.55 (SEM 1.98)% in the patients v 2.49 (SEM 0.96)% in the controls). Partial diabetes insipidus is apparently common in Sheehan's syndrome. This association should be borne in mind when managing these patients, especially those in acute failure.
20例产后垂体功能减退患者接受了禁水试验，随后给予合成精氨酸加压素（去氨加压素；弥凝）。通过基础状态下以及联合使用促黄体生成素释放激素 - 促甲状腺激素释放激素 - 胰岛素刺激后的激素测定确诊全垂体功能减退。所有患者均接受了氢化可的松和甲状腺激素替代治疗。将结果与12名正常女性的结果进行比较。与对照组相比，患者的尿浓缩能力降低（患者最大尿渗透压为688（标准误23）mmol（毫渗摩尔）/kg，对照组为967（标准误29）mmol/kg）。此外，患者给予去氨加压素后尿渗透压的变化更大（患者为+9.55（标准误1.98）%，对照组为2.49（标准误0.96）%）。部分性尿崩症在席汉综合征中显然很常见。在管理这些患者时，尤其是那些急性衰竭患者时，应牢记这种关联。
