[抑制胰岛朗格汉斯细胞分泌胰岛素的单克隆自身抗体的产生]
[Production of monoclonal autoantibodies inhibiting the secretion of insulin by the islets of Langerhans].
作者信息
Dardenne M, Debray-Sachs M, Savino W, Bach J F
出版信息
C R Acad Sci III. 1984;298(18):523-6.
PMID:6432224
Abstract
Monoclonal autoantibodies cytotoxic for murine islet cells have been obtained by cell fusion using spleen cells from non-immunized diabetic C57BL/KsJ (db/db) Mice. These monoclonals, of IgG2a subclass, blocked in vitro insulin secretion induced by arginine in Mouse pancreatic cells.
摘要
利用来自未免疫的糖尿病C57BL/KsJ（db/db）小鼠的脾细胞，通过细胞融合获得了对小鼠胰岛细胞具有细胞毒性的单克隆自身抗体。这些IgG2a亚类的单克隆抗体在体外阻断了精氨酸诱导的小鼠胰腺细胞胰岛素分泌。
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[Production of monoclonal autoantibodies inhibiting the secretion of insulin by the islets of Langerhans].[抑制胰岛朗格汉斯细胞分泌胰岛素的单克隆自身抗体的产生]
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