Morris D V, Adeniyi-Jones R, Wheeler M, Sonksen P, Jacobs H S
Clin Endocrinol (Oxf). 1984 Aug;21(2):189-200. doi: 10.1111/j.1365-2265.1984.tb03459.x.
The effects of chronic subcutaneous infusion of luteinising hormone-releasing hormone (LHRH) have been studied in a group of 17 male patients with hypogonadotrophic hypogonadism (HH). Ten of the patients had primary and seven secondary failure of gonadotrophin release, and all but four had previously been treated with gonadotrophin injections. Treatment was continued for between one and 18 months and was well tolerated by all except one patient who became allergic to LHRH. An increase in the basal gonadotrophin concentrations occurred in all except four patients within one week of the initiation of therapy, and this was associated with a rise in the serum testosterone level in eight patients. Increased spermatogenesis was demonstrated in seven cases and three pregnancies have resulted thus far. Pituitary desensitisation to the effects of LHRH was found in five subjects with primary HH who failed to produce any increase in testosterone secretion despite an initial stimulation of gonadotrophin release. We conclude that chronic pulsatile infusion of LHRH is an effective technique for the treatment of some cases of hypogonadotrophic hypogonadism.
对一组17名低促性腺激素性性腺功能减退（HH）男性患者进行了慢性皮下注射促黄体生成素释放激素（LHRH）的效果研究。其中10例患者为原发性促性腺激素释放失败，7例为继发性促性腺激素释放失败，除4例患者外，其余患者此前均接受过促性腺激素注射治疗。治疗持续1至18个月，除1例对LHRH过敏的患者外，所有患者耐受性良好。除4例患者外，所有患者在开始治疗的一周内基础促性腺激素浓度均升高，其中8例患者血清睾酮水平随之升高。7例患者精子发生增加，迄今已有3例妊娠。在5例原发性HH患者中发现垂体对LHRH作用脱敏，尽管最初促性腺激素释放受到刺激，但睾酮分泌未出现任何增加。我们得出结论，慢性脉冲式注射LHRH是治疗某些低促性腺激素性性腺功能减退病例的有效技术。
