Armstrong R D, Faith A, Panayi G S, Batchelor J R
Clin Rheumatol. 1983 Jun;2(2):183-8. doi: 10.1007/BF02032178.
We describe a patient with rheumatoid arthritis who developed a sudden, severe thrombocytopenia during the early stages of treatment with sodium aurothiomalate. There were no haemorrhagic manifestations and the thrombocytopenia was rapidly corrected by corticosteroid treatment. The presence of anti-platelet IgG was demonstrated in serial serum specimens by an enzyme-linked immunosorbent assay (ELISA). Although most of this reactivity proved to be directed against allogeneic antigens on donor platelets, IgG reactive with autologous platelets was detected in the first serum sample obtained.
我们描述了一名类风湿性关节炎患者，该患者在金硫代苹果酸钠治疗的早期阶段突然出现严重血小板减少症。无出血表现，血小板减少症通过皮质类固醇治疗迅速得到纠正。通过酶联免疫吸附测定（ELISA）在系列血清标本中证实了抗血小板IgG的存在。尽管这种反应性大多被证明是针对供体血小板上的同种异体抗原，但在获得的第一份血清样本中检测到了与自体血小板反应的IgG。
