金过敏反应机制的免疫学研究。
Immunological studies on the mechanism of gold hypersensitivity reactions.
作者信息
Davis P, Ezeoke A, Munro J, Hobbs J R, Hughes G R
出版信息
Br Med J. 1973 Sep 29;3(5882):676-8. doi: 10.1136/bmj.3.5882.676.
Abstract
Immunological studies were performed on 12 patients with rheumatoid arthritis who developed reactions to gold. IgE levels were found to be raised in 10 of 11 patients tested at the time of the gold reaction, returning to normal on stopping therapy. Two of 12 patients with gold reactions had positive in-vitro lymphocyte transformation responses to gold.It is suggested that dermatological side effects in particular are mediated by a type I hypersensitivity response.
摘要
对12例对金制剂产生反应的类风湿关节炎患者进行了免疫学研究。在金制剂反应发生时检测的11例患者中，有10例IgE水平升高，停止治疗后恢复正常。12例有金制剂反应的患者中有2例对金制剂的体外淋巴细胞转化反应呈阳性。提示特别是皮肤副作用是由I型超敏反应介导的。
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