Fliess E L, Ortiz M C, Corn J
Hansenol Int. 1983 Jun;8(1):9-17.
The cell mediated immunity (CMI) to protein purified derivates of Mycobacterium leprae, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium marinum was studied. Leukocyte Migration Inhibition (LMI) and Delayed Hypersensitivity skin reactions to these antigens were examined in 44 hanseniasis patients (20 quiescent Virchowians, 13 reactional Virchowians and 11 tuberculoid patients) and 15 healthy subjects. An impairment in LMI and Delayed Hypersensitivity tests to M. leprae and M. marinum was observed in Virchowians patients both quiescent and reactional. The CMI response to all mycobacterial antigens was increased in tuberculoid patients and was observed a poor response to M. leprae and M. marinum in healthy controls. Our results show a high correlation between the CMI response to M. leprae and to M. marinum (r = + 0,8). This close relationship between both antigens may express cross-reactivity.
研究了对麻风分枝杆菌、结核分枝杆菌、鸟分枝杆菌和海分枝杆菌蛋白纯化衍生物的细胞介导免疫（CMI）。在44例麻风病患者（20例静止期维丘型、13例反应期维丘型和11例结核样型患者）和15名健康受试者中检测了对这些抗原的白细胞迁移抑制（LMI）和迟发型超敏皮肤反应。在静止期和反应期的维丘型患者中均观察到对麻风分枝杆菌和海分枝杆菌的LMI及迟发型超敏试验受损。结核样型患者对所有分枝杆菌抗原的CMI反应增强，而在健康对照中观察到对麻风分枝杆菌和海分枝杆菌的反应较差。我们的结果显示对麻风分枝杆菌和海分枝杆菌的CMI反应之间存在高度相关性（r = +0.8）。这两种抗原之间的这种密切关系可能表现为交叉反应性。
