通过非免疫原性抗原形式维持免疫自身耐受性。
Maintenance of immunologic self-tolerance by nonimmunogenic forms of antigen.
作者信息
Swanborg R H
出版信息
Clin Exp Immunol. 1976 Dec;26(3):597-600.
Immunologic tolerance to EAE in guinea-pigs appears to be a function of a determinant distinct from the encephalitogenic region of the myelin basic protein molecule. In Lewis rats (in which species the molecular sites for disease-induction and tolerance have not been completely characterized) the mechanism underlying this state of immunologic tolerance involves suppressor cell regulation of the autoimmune response. On the basis of these experimental findings we postulate that natural self-tolerance is maintained by suppressor T cells which are stimulated by nonimmunogenic fragments of self-antigen released during protein turnover.
豚鼠对实验性自身免疫性脑脊髓炎（EAE）的免疫耐受似乎是由一个与髓鞘碱性蛋白分子致脑炎区域不同的决定簇所决定的。在Lewis大鼠中（在该物种中，疾病诱导和耐受的分子位点尚未完全明确），这种免疫耐受状态的潜在机制涉及自身免疫反应的抑制性细胞调节。基于这些实验结果，我们推测天然自身耐受是由抑制性T细胞维持的，这些抑制性T细胞受到蛋白质代谢过程中释放的自身抗原非免疫原性片段的刺激。
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