Fujita M, Fujita F, Taguchi T
Gan No Rinsho. 1984 Jul;30(9 Suppl):1168-74.
For evaluating the predictive value of experimental chemotherapy of human cancers xenografted to nude mice, two types of comparison between experimental responses in nude mouse system and their clinical results were made. The responses of 12 experimental therapies with single agent or drug combination were directly compared with those of the same kinds of therapy in each donor patient. Satisfactory agreement between the two results was shown in every comparison, with 3 true positives and 9 true negatives. Using 15 human cancer lines consisting of 7 gastric, 3 colorectal, 2 pancreatic and 3 breast cancers, single agent treatment with 6 drugs (MMC, ADR, ACNU, FT-207, 5'-DFUR) were performed. The effectiveness of each drug to these xenografts was in good accordance with the known clinical effect of each drug in the same type of cancer. Nude mouse-human cancer panel is useful for the secondary screening of the new drug.
为评估人癌裸鼠移植瘤实验化疗的预测价值，在裸鼠系统的实验反应与其临床结果之间进行了两种类型的比较。将12种单药或联合用药的实验疗法的反应与每个供体患者相同类型疗法的反应进行了直接比较。每次比较中两种结果之间均显示出令人满意的一致性，有3个真阳性和9个真阴性。使用由7种胃癌、3种结直肠癌、2种胰腺癌和3种乳腺癌组成的15种人癌细胞系，用6种药物（丝裂霉素、阿霉素、嘧啶亚硝脲、替加氟、去氧氟尿苷）进行了单药治疗。每种药物对这些移植瘤的有效性与每种药物在同一类型癌症中的已知临床效果高度一致。裸鼠-人癌模型可用于新药的二次筛选。
