Yamaguchi T, Kuroda Y, Saito M, Ebina T, Hoshino F, Ishida N
Microbiol Immunol. 1984;28(5):601-10. doi: 10.1111/j.1348-0421.1984.tb00712.x.
In mouse spleen cell cultures, TH69, a live Streptococcus faecalis (ATCC 31663) preparation, at a concentration of 20 micrograms/ml induced immune interferon (IFN gamma) with molecular weight ranging from 20,000 to 40,000 daltons together with a small amount of IFN alpha/beta. By using nonsensitized mouse spleen cells, the fact that both T-cells and macrophages are required for this IFN production was established. When these spleen cells were obtained from mice sensitized 12 days earlier with 4 mg of TH69, twice as much IFN was produced than in cells obtained from nonsensitized mice. This increase was explained by the presence of both sensitized macrophages and T-cells in a reconstitution experiment.
在小鼠脾细胞培养物中，粪肠球菌（ATCC 31663）活菌制剂TH69，浓度为20微克/毫升时，可诱导分子量在20,000至40,000道尔顿之间的免疫干扰素（IFNγ）以及少量的IFNα/β。通过使用未致敏的小鼠脾细胞，证实了这种干扰素产生需要T细胞和巨噬细胞两者。当这些脾细胞取自12天前用4毫克TH69致敏的小鼠时，产生的干扰素是从未致敏小鼠获得的细胞的两倍。在一项重组实验中，致敏巨噬细胞和T细胞的存在解释了这种增加。
