Tuschl H, Kovac R, Wolf A, Smolen J S
Mutat Res. 1984 Sep;128(2):167-71. doi: 10.1016/0027-5107(84)90104-0.
The frequency of sister-chromatid exchanges (SCEs) was investigated in peripheral lymphocytes of lupus erythematosus patients and compared with values obtained for healthy controls. Irrespective of the kind of medical treatment, an increased level of spontaneously occurring SCEs could be demonstrated in lupus patients. In addition to spontaneously occurring SCEs, mitomycin C (MMC)-induced SCEs were evaluated. No difference between patients and controls was found with respect to MMC-induced SCEs.
研究了红斑狼疮患者外周血淋巴细胞中姐妹染色单体交换（SCE）的频率，并与健康对照者的结果进行了比较。无论采用何种治疗方式，均可证明狼疮患者自发发生的SCE水平升高。除了自发发生的SCE外，还评估了丝裂霉素C（MMC）诱导的SCE。在MMC诱导的SCE方面，未发现患者与对照之间存在差异。
