Wilks J W
Acta Endocrinol (Copenh). 1984 Aug;106(4):538-43. doi: 10.1530/acta.0.1060538.
This study was undertaken to determine if early follicular phase administration of a synthetic luteinizing hormone releasing hormone (LRH) agonist would produce luteal phase defects in the monkey. [D-His(im-Bzl)6,Pro9]LRH N-ethylamide was administered to groups of rhesus monkeys on days 1-3 of the menstrual cycle. Two responses were observed: a) anovulatory menstrual cycles of less than 14 days duration, and b) ovulatory menstrual cycles characterized by unusually long follicular phases. All 4 monkeys with shortened menstrual cycles had prominent increases in serum gonadotrophin and oestradiol concentrations during treatment with the LRH agonist; early menses in these animals was attributed to uterine bleeding upon oestrogen withdrawal. Serum FSH concentrations declined, serum LH concentrations were unaltered, and only 2 of 8 monkeys had elevations in serum oestradiol during ovulatory menstrual cycles. The mean interval from cessation of treatment with the LRH agonist to the next preovulatory gonadotrophin surge was 21.5 +/- 3.2 days in ovulatory menstrual cycles. Corpus luteum function was normal following treatment with the LRH agonist in ovulatory cycles. The results indicate that both the long and short menstrual cycles observed following early follicular phase administration of the LRH agonist to monkeys can be attributed to a profound inhibition in follicle recruitment. [D-His(im-Bzl)6,Pro9]LRH N-ethylamide did not alter corpus luteum function in the monkeys.
本研究旨在确定在卵泡早期给予合成促黄体生成素释放激素（LRH）激动剂是否会在猴子身上产生黄体期缺陷。在月经周期的第1 - 3天，将[D - His(im - Bzl)6,Pro9]LRH N - 乙酰胺给予恒河猴组。观察到两种反应：a）持续时间少于14天的无排卵月经周期，以及b）以异常长的卵泡期为特征的排卵月经周期。所有月经周期缩短的4只猴子在用LRH激动剂治疗期间血清促性腺激素和雌二醇浓度显著升高；这些动物的早期月经归因于雌激素撤退后的子宫出血。血清FSH浓度下降，血清LH浓度未改变，并且在排卵月经周期中8只猴子中只有2只血清雌二醇升高。在排卵月经周期中，从停止使用LRH激动剂治疗到下一次排卵前促性腺激素激增的平均间隔时间为21.5±3.2天。在排卵周期中用LRH激动剂治疗后黄体功能正常。结果表明，在猴子卵泡早期给予LRH激动剂后观察到的长月经周期和短月经周期都可归因于卵泡募集的深度抑制。[D - His(im - Bzl)6,Pro9]LRH N - 乙酰胺未改变猴子的黄体功能。
