Rothhut B, Russo-Marie F
Agents Actions Suppl. 1984;14:171-80.
Since the discovery that cortisone could be used as an anti-inflammatory agent, this compound and synthetic anti-inflammatory steroids have been widely used in all inflammatory and allergic diseases. Anti-inflammatory steroids have been reported to act on almost all steps of the inflammatory reaction. Nevertheless their molecular mechanism of action has remained poorly understood, in opposition to non steroidal anti-inflammatory drugs whose mechanism is now well known. We report here recent data concerning their molecular mechanism of action. These recent results have all led to the conclusion that part of their action can be explained by the synthesis "de novo" of one or more proteins which then will inhibit the deacylation of arachidonic acid from membrane phospholipids. Whether the action of this or these proteins can explain all the known anti-inflammatory actions of steroids remains to be investigated.
自从发现可的松可作为抗炎剂以来，这种化合物和合成抗炎类固醇已广泛应用于所有炎症和过敏性疾病。据报道，抗炎类固醇几乎作用于炎症反应的所有步骤。然而，与机制现已为人熟知的非甾体抗炎药相反，它们的分子作用机制仍知之甚少。我们在此报告有关其分子作用机制的最新数据。这些最新结果均得出这样的结论，即它们的部分作用可以通过一种或多种蛋白质的“从头”合成来解释，这些蛋白质随后将抑制花生四烯酸从膜磷脂的脱酰作用。这种或这些蛋白质的作用是否能解释类固醇所有已知的抗炎作用仍有待研究。
