Blackwell G J, Carnuccio R, Di Rosa M, Flower R J, Parente L, Persico P
Nature. 1980 Sep 11;287(5778):147-9. doi: 10.1038/287147a0.
Anti-inflammatory glucocorticoids inhibit prostaglandin (PG) biosynthesis by preventing arachidonic acid release from phospholipids rather than inhibiting the cyclooxygenase. As in other cells, this steroid action depends on receptor occupation and de novo protein/RNA biosynthesis. We have previously shown in guinea pig perfused lungs and rat peritoneal leukocytes that the effect of steroids in PG generation is mediated by an uncharacterized 'second messenger'. Now, we report that this factor (which we have named 'macrocortin') is an intracellular polypeptide whose release and synthesis are stimulated by steroids. Macrocortin derived from rat peritoneal leukocytes is very similar to that released from guinea pig lungs.
抗炎糖皮质激素通过阻止花生四烯酸从磷脂中释放来抑制前列腺素（PG）的生物合成，而不是抑制环氧化酶。与其他细胞一样，这种类固醇作用取决于受体占据以及从头进行的蛋白质/RNA生物合成。我们先前在豚鼠灌注肺和大鼠腹膜白细胞中已表明，类固醇在PG生成中的作用是由一种未明确的“第二信使”介导的。现在，我们报告该因子（我们已将其命名为“巨皮质素”）是一种细胞内多肽，其释放和合成受类固醇刺激。源自大鼠腹膜白细胞的巨皮质素与从豚鼠肺中释放的非常相似。
