Seaworth B J, Garrett L E, Stead W W, Hamilton J D
Am J Nephrol. 1984;4(4):235-9. doi: 10.1159/000166815.
To define the incidence of non-A, non-B (NANB) hepatitis and evaluate possible risk factors, we reviewed records of 163 patients on chronic dialysis during a 3-year period. 23 cases of NANB hepatitis occurred, 13 (27%) in 49 center dialysis, 8 (10%) in 77 home hemodialysis (p less than 0.02) and 2 (5%) in 37 peritoneal dialysis patients (p less than 0.01). Hepatitis patients received significantly more transfusions than controls. Numbers of transfusions and of patients transfused were not significantly different in center patients compared to home and peritoneal. 8 NANB patients received no transfusions. NANB was the most common cause of hepatitis in our unit (68%). Although transfusions were a likely etiologic factor, to explain the increased risk in center dialysis patients, disease in patients not transfused and development of NANB hepatitis without a known parenteral exposure in a physician assigned to the Nephrology Service, we feel another etiologic factor was important, the dialysis center.
为了确定非甲非乙型（NANB）肝炎的发病率并评估可能的危险因素，我们回顾了163例慢性透析患者在3年期间的记录。发生了23例NANB肝炎，49例中心透析患者中有13例（27%），77例家庭血液透析患者中有8例（10%）（p<0.02），37例腹膜透析患者中有2例（5%）（p<0.01）。肝炎患者接受输血的次数明显多于对照组。中心透析患者的输血次数和接受输血的患者数量与家庭透析和腹膜透析患者相比无显著差异。8例NANB患者未接受输血。NANB是我们科室肝炎最常见的病因（68%）。虽然输血可能是一个病因，但为了解释中心透析患者风险增加的原因，未输血患者的疾病以及在肾病科工作的一名医生身上出现的无已知肠道外暴露的NANB肝炎，我们认为另一个病因很重要，即透析中心。
