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血液透析中可能的非甲非乙型肝炎

Presumable non-A, non-B hepatitis in hemodialysis.

作者信息

Gmelin K, Doerr H W, Severin R, Bommer J, von Ehrlich-Treuenstätt B, Ritz E, Kommerell B

出版信息

Zentralbl Bakteriol Mikrobiol Hyg B. 1982 Apr;176(1):28-38.

PMID:6287760
Abstract

Hepatitis A and B markers, IgM-anti-CMV and -EBV were determined in 154 dialysis patients, 118 relatives of patients and 42 members of the staff. Episodes of elevated transaminases were investigated for presumable non-A, non-B hepatitis as well as secondary infections among relatives. --The cumulative frequency of HBV markers was 71% in center dialysis patients, 63% in home dialysis patients, 50% in staff and 19% in relatives. The frequency of HBV markers increased with duration of dialysis treatment and with the number of blood units transfused. Spouses of dialysis patients had more often HBV markers than other relatives (22% vs. 8.8%). 96.8% of the center dialysis patients, 83.3% of home-dialysis patients, 41% of the staff, and 42% of the relatives were anti-HAV-positive. The incidence of IgM-anti-CMV was highest in home-dialysis patients (15.5%). The frequency of IgM-anti-EBV was 4.3% in center-dialysis patients and 12.7% in home-dialysis patients. --9% of all dialysis patients had an episode of elevated transaminases compatible with non-A, non-B hepatitis. The possible secondary attack rate among relatives was 31%.

摘要

对154例透析患者、118例患者亲属和42名工作人员检测了甲型和乙型肝炎标志物、IgM抗巨细胞病毒和抗EB病毒。对转氨酶升高的发作情况进行调查,以确定可能的非甲非乙型肝炎以及亲属中的继发感染情况。——中心透析患者中乙肝标志物的累积频率为71%,家庭透析患者中为63%,工作人员中为50%,亲属中为19%。乙肝标志物的频率随透析治疗时间和输血单位数量的增加而升高。透析患者的配偶比其他亲属更常出现乙肝标志物(22%对8.8%)。96.8%的中心透析患者、83.3%的家庭透析患者、41%的工作人员和42%的亲属抗甲型肝炎病毒呈阳性。家庭透析患者中IgM抗巨细胞病毒的发生率最高(15.5%)。中心透析患者中IgM抗EB病毒的频率为4.3%,家庭透析患者中为12.7%。——所有透析患者中有9%出现了与非甲非乙型肝炎相符的转氨酶升高发作。亲属中可能的继发感染率为31%。

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