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[神经安定麻醉在儿童腺样体扁桃体切除术中的应用]

[The use of neuroleptanesthesia in adenotonsillectomy in children].

作者信息

Jung C, Meisel G, Wiedemann K

出版信息

Anasth Intensivther Notfallmed. 1984 Jun;19(3):112-6.

PMID:6433737
Abstract

Two groups of 100 children each who underwent adenoidectomy and/or tonsillectomy were anaesthetised by halothane 1% or by a neuroleptic technique (NLA) using fentanyl 0.0025 mg/kg and droperidol 0.125 mg/kg as a fixed combination (Thalamonal). Both techniques were supplemented with nitrous oxide/oxygen 4/2 l. All children were premedicated with atropine 0.015 mg/kg, fentanyl 0.0025 mg/kg and droperidol 0.125 mg/kg i.m. Quality of premedication and postoperative behaviour and analgesia were assessed by standardised criteria. 93% of the patients arrived at the theatre sleeping or detached, 75% showed almost no reactions to venipuncture. Heart rate during surgery in both groups increased by 13%, mean arterial blood pressure in the NLA group increased by 9% and in the halothane group dropped by 5%. Postoperatively blood pressure in NLA patients returned to normal, while in the halothane group there was a transient rise by 10%. Protective reflexes and consciousness were restored in the NLA group earlier. After halothane, stridor occurred in eight cases upon extubation. Postoperative analgesia scores in NLA patients were double those in the halothane group. Moderate metabolic acidosis and slight hypercapnia were postoperatively present in both groups twice. Modified neuroleptanaesthesia proved equal to halothane anaesthesia for ENT surgery. No respiratory depression was seen. Advantages like uncomplicated quick recovery and protracted postoperative analgesia are opposed by disadvantages like inferior vegetative blockade and inferior pharmacokinetics. Close postoperative supervision in a recovery room is a prerequisite to using this NLA technique.

摘要

两组各100名接受腺样体切除术和/或扁桃体切除术的儿童,分别用1%氟烷或采用神经安定技术(NLA)麻醉,后者使用0.0025mg/kg芬太尼和0.125mg/kg氟哌利多作为固定组合(氟芬合剂)。两种技术均补充氧化亚氮/氧气4/2L。所有儿童均经肌肉注射0.015mg/kg阿托品、0.0025mg/kg芬太尼和0.125mg/kg氟哌利多进行术前用药。通过标准化标准评估术前用药质量、术后行为和镇痛情况。93%的患者到达手术室时处于睡眠或放松状态,75%的患者对静脉穿刺几乎无反应。两组手术期间心率均增加13%,NLA组平均动脉血压增加9%,氟烷组下降5%。术后,NLA组患者血压恢复正常,而氟烷组有短暂10%的升高。NLA组保护性反射和意识恢复较早。氟烷麻醉后,8例患者拔管时出现喘鸣。NLA组患者术后镇痛评分是氟烷组的两倍。两组术后均出现两次中度代谢性酸中毒和轻度高碳酸血症。改良神经安定麻醉在耳鼻喉科手术中被证明与氟烷麻醉效果相当。未见呼吸抑制。像恢复简单快速和术后镇痛持久这样的优点,被诸如植物神经阻滞效果较差和药代动力学不佳这样的缺点所抵消。术后在恢复室进行密切监测是使用这种NLA技术的前提条件。

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