Yayoi E, Kobayashi T, Inaji H, Maeura Y, Mori T
Gan To Kagaku Ryoho. 1984 Aug;11(8):1683-6.
A 44-year-old premenopausal woman with metastatic breast cancer to the bones was treated with tamoxifen and tegafur followed by a minimal dose of tamoxifen alone, with complete response for more than 90 months. Initially, tamoxifen was given with a dose of 20 mg daily in combination with 600 mg daily of tegafur for 22 months, a remission of low back pain and recalcification of the lytic lesion in the pelvis. After reduction of tamoxifen dose to 10 mg/daily and withdrawal of tegafur, regression of the disease continued for another 68+ months. Bone metastasis completely disappeared, and the patient is still in remission. No significant side effects from tamoxifen were encountered. Tamoxifen appears to be a useful and safe treatment for recurrent breast cancer.
