Gordon G, Grundy E M, Al-Khudhairi D, Anderson D J, Whitwam J G
Br J Anaesth. 1984 Oct;56(10):1161-5. doi: 10.1093/bja/56.10.1161.
Experiments were performed on 14 anaesthetized, artifically ventilated dogs, in which efferent activity in the phrenic nerve was recorded and blood-gas tensions, arterial pH and core temperature were controlled. Doses of midazolam between 0.2 mg kg-1 and 2 mg kg-1 abolished phrenic nerve activity for periods between 30 and 90 min. Ro 15-1788 in doses between 0.06 mg kg-1 and 1 mg kg-1 and Ro 15-3505 0.2-2 mg kg-1 reversed the effects of midazolam on phrenic nerve activity. Prior administration of these drugs either abolished or greatly inhibited the action of midazolam. When the preparations were observed for up to 2 h, there was no evidence of return of the action of midazolam, suggesting that both antagonists had a duration of action at least as long as that of midazolam.
对14只麻醉、人工通气的狗进行了实验，记录膈神经的传出活动，并控制血气张力、动脉pH值和核心温度。剂量在0.2毫克/千克至2毫克/千克之间的咪达唑仑可使膈神经活动消失30至90分钟。剂量在0.06毫克/千克至1毫克/千克之间的Ro 15 - 1788和0.2至2毫克/千克的Ro 15 - 3505可逆转咪达唑仑对膈神经活动的影响。预先给予这些药物可消除或极大地抑制咪达唑仑的作用。当对这些制剂观察长达2小时时，没有证据表明咪达唑仑的作用恢复，这表明两种拮抗剂的作用持续时间至少与咪达唑仑一样长。
