Lees G J, Kydd R R, Horsburgh R J, Wright J J
Brain Res. 1984 Aug 6;308(1):155-8. doi: 10.1016/0006-8993(84)90928-4.
The ability of nomifensine to protect the dopaminergic cells of the substantia nigra and ventral tegmental areas against 6-hydroxydopamine-induced destruction was evaluated. Nomifensine at high doses (20 mg/kg, i.p.) protected the cells from the effects of low amounts of 6-hydroxydopamine (2 micrograms) injected intracerebrally. This protective effect was markedly decreased with an increased amount of 6-hydroxydopamine (8 micrograms), or by lower doses of nomifensine (6.7 mg/kg). These doses of nomifensine are higher than those required to protect dopaminergic nerve terminals.
评估了诺米芬辛保护黑质和腹侧被盖区多巴胺能细胞免受6-羟基多巴胺诱导破坏的能力。高剂量（20mg/kg，腹腔注射）的诺米芬辛可保护细胞免受脑内注射少量6-羟基多巴胺（2微克）的影响。随着6-羟基多巴胺量的增加（8微克）或诺米芬辛剂量降低（6.7mg/kg），这种保护作用明显减弱。这些诺米芬辛剂量高于保护多巴胺能神经末梢所需的剂量。
