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血管活性药物与人体动脉在体内的弹性特性,特别提及硝酸甘油的作用。

Vasoactive drugs and elastic properties of human arteries in vivo, with special reference to the action of nitroglycerine.

作者信息

Westling H, Jansson L, Jonson B, Nilsén R

出版信息

Eur Heart J. 1984 Aug;5(8):609-16. doi: 10.1093/oxfordjournals.eurheartj.a061716.

DOI:10.1093/oxfordjournals.eurheartj.a061716
PMID:6434312
Abstract

Pulsatile changes in the volume of an arm segment were recorded with an air-filled plethysmograph and related to intra-arterial blood pressure. Alterations in transmural arterial pressure were obtained by changing the pressure in a large chamber surrounding the entire arm. Arterial compliance values were calculated in late diastole when pressure and volume changes were slow. Compliance varied with transmural arterial pressure in a hyperbolic manner, rising steeply at low pressure. Noradrenaline and hypertensin did not change the arterial compliance values, while dihydroergotamine reduced them. Nitroglycerine caused a pronounced increase in compliance values in doses that did not change cardiac output and arterial pressure.

摘要

用充气体积描记器记录手臂段体积的搏动变化,并将其与动脉内血压相关联。通过改变环绕整个手臂的大腔室内的压力来获得跨壁动脉压的变化。在舒张末期压力和体积变化缓慢时计算动脉顺应性值。顺应性以双曲线方式随跨壁动脉压变化,在低压时急剧上升。去甲肾上腺素和高血压素不改变动脉顺应性值,而双氢麦角胺降低它们。硝酸甘油在不改变心输出量和动脉压的剂量下使顺应性值显著增加。

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1
Vasoactive drugs and elastic properties of human arteries in vivo, with special reference to the action of nitroglycerine.血管活性药物与人体动脉在体内的弹性特性,特别提及硝酸甘油的作用。
Eur Heart J. 1984 Aug;5(8):609-16. doi: 10.1093/oxfordjournals.eurheartj.a061716.
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