Gerendai I, Nemeskéri A, Csernus V
Exp Clin Endocrinol. 1984 Jul;84(1):27-36. doi: 10.1055/s-0029-1210363.
The effect of the neurotoxic drug, 6-hydroxy-dopamine (6-OHDA) on the testicular growth, the compensatory testicular hypertrophy, the testicular cytology and the serum testosterone level was studied in immature rats. Unilateral injection of 33 micrograms of 6-OHDA beneath the testicular capsule in animals with two testes did not alter the weight of the gonads but promoted the development of both testes. Unilateral injection of 333 micrograms of 6-OHDA resulted in a decreased weight and severe atrophy of the treated gonad, while a significant weight gain of the contralateral testis occurred. In hemicastrated rats 33 micrograms of 6-OHDA into the remaining testis caused an enhanced compensatory testicular hypertrophy. When 333 micrograms of 6-OHDA was administered beneath the capsule of the remaining testis a diminished compensatory testicular hypertrophy occurred but no signs of degeneration could be observed. Data indicate that the testicular adrenergic elements play a role in the testicular growth, in the development of compensatory testicular hypertrophy and in the cytodifferentiation of the immature testis.
在未成熟大鼠中研究了神经毒性药物6-羟基多巴胺（6-OHDA）对睾丸生长、代偿性睾丸肥大、睾丸细胞学及血清睾酮水平的影响。在双侧睾丸动物的睾丸被膜下单侧注射33微克6-OHDA，未改变性腺重量，但促进了双侧睾丸的发育。单侧注射333微克6-OHDA导致处理侧性腺重量减轻及严重萎缩，而对侧睾丸则出现显著增重。在半阉割大鼠中，向剩余睾丸注射33微克6-OHDA可导致代偿性睾丸肥大增强。当在剩余睾丸被膜下注射333微克6-OHDA时，代偿性睾丸肥大减弱，但未观察到退化迹象。数据表明，睾丸肾上腺素能元件在睾丸生长、代偿性睾丸肥大的发展及未成熟睾丸的细胞分化中起作用。
