Britten A, Etzel F, Ala F, Carman C, Smit Sibinga C
Haematologia (Budap). 1983;16(1-4):109-20.
Demand for factor VIII varies greatly and exceeds supply in many places. Logical analysis of this difficult situation has been undertaken by observing actual usage, calculating potential need, and analysing factors which limit or influence production and distribution. Usage exceeds production potential in some places. It is concluded that factor VIII production/usage in the range of 20 000-60 000 IU per hemophilia A patient per year is both feasible and adequate. Production/use below 10 000 IU is not adequate. Production above 60 000 IU is not practicable using current technology.
对凝血因子VIII的需求差异很大，在许多地方供不应求。针对这一困境，已通过观察实际用量、计算潜在需求以及分析限制或影响生产与供应的因素进行了逻辑分析。在某些地方，用量超过了生产潜力。得出的结论是，每年每位甲型血友病患者使用20000 - 60000国际单位的凝血因子VIII既可行又充足。低于10000国际单位的生产/用量是不够的。使用现有技术，超过60000国际单位的生产是不可行的。
