鼠伤寒沙门氏菌中一种肽转运基因的厌氧和亮氨酸依赖性表达。
Anaerobic and leucine-dependent expression of a peptide transport gene in Salmonella typhimurium.
作者信息
Jamieson D J, Higgins C F
出版信息
J Bacteriol. 1984 Oct;160(1):131-6. doi: 10.1128/jb.160.1.131-136.1984.
Abstract
Using Mu d1-mediated lac operon fusions, we studied the transcriptional regulation of the genes encoding two peptide transport systems, the oligopeptide permease and the tripeptide permease. The four opp genes were found to be constitutively expressed, whereas the genes encoding the tripeptide permease are under a complex set of regulatory controls. Two loci, tppA and tppB, are required for tripeptide permease function. Locus tppA is shown to be a positive regulator of tppB expression. In addition, tppB expression is specifically induced by exogeneous leucine or by anaerobiosis. Anaerobic induction of tppB is independent of the fnr gene product which is required for the anaerobic expression of several respiratory enzymes. Thus, there must be at least two distinct pathways for the anaerobic regulation of gene expression.
摘要
利用 Mud1 介导的乳糖操纵子融合技术，我们研究了编码两种肽转运系统（寡肽通透酶和三肽通透酶）的基因的转录调控。发现四个 opp 基因组成型表达，而编码三肽通透酶的基因则受到一组复杂的调控控制。三肽通透酶功能需要两个位点，tppA 和 tppB。已证明位点 tppA 是 tppB 表达的正调控因子。此外，tppB 的表达受到外源亮氨酸或厌氧条件的特异性诱导。tppB 的厌氧诱导不依赖于 fnr 基因产物，而 fnr 基因产物是几种呼吸酶厌氧表达所必需的。因此，基因表达的厌氧调控必定至少有两条不同的途径。
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Anaerobic and leucine-dependent expression of a peptide transport gene in Salmonella typhimurium.鼠伤寒沙门氏菌中一种肽转运基因的厌氧和亮氨酸依赖性表达。
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Genetic organization of the oligopeptide permease (opp) locus of Salmonella typhimurium and Escherichia coli.鼠伤寒沙门氏菌和大肠杆菌寡肽通透酶（opp）基因座的遗传组织
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Linkage map of Salmonella typhimurium, Edition VI.鼠伤寒沙门氏菌连锁图谱，第六版。
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