Foster C M, Comite F, Pescovitz O H, Ross J L, Loriaux D L, Cutler G B
J Clin Endocrinol Metab. 1984 Oct;59(4):801-5. doi: 10.1210/jcem-59-4-801.
Six girls with McCune-Albright syndrome were treated for at least 2 months with the long-acting LHRH agonist D-Trp6-Pro9-NEt-LHRH, which previously was found to be an effective treatment for true precocious puberty. Nocturnal and LHRH-stimulated serum gonadotropin levels and plasma estradiol levels were measured before treatment and after 2-3 months of treatment. Five of the six girls had no decrease in serum gonadotropin or plasma estradiol levels during therapy, and their pubertal signs were unaffected by treatment. All five of these girls had serum gonadotropin levels that were within or below the normal prepubertal range. The sixth girl, who had gonadotropin levels in the normal pubertal range before treatment, had decreased serum gonadotropin and plasma estradiol levels during 1 yr of LHRH analog therapy. This was associated with cessation of menses and regression of secondary sexual changes. The failure of LHRH analog to modify the course of precocious puberty in the five patients with prepubertal serum gonadotropin concentrations is further evidence that the mechanism of precocious puberty in most girls with McCune-Albright syndrome differs from that in patients with true precocious puberty.
六名患有McCune - Albright综合征的女孩接受了长效促性腺激素释放激素（LHRH）激动剂D - Trp6 - Pro9 - Net - LHRH治疗，疗程至少2个月。此前发现该药物对真性性早熟有效。在治疗前以及治疗2 - 3个月后，测量了夜间及LHRH刺激后的血清促性腺激素水平和血浆雌二醇水平。六名女孩中有五名在治疗期间血清促性腺激素或血浆雌二醇水平未下降，其青春期体征也未受治疗影响。这五名女孩的血清促性腺激素水平均在正常青春期前范围或低于该范围。第六名女孩在治疗前促性腺激素水平处于正常青春期范围，在接受LHRH类似物治疗1年期间，血清促性腺激素和血浆雌二醇水平下降。这与月经停止和第二性征消退有关。LHRH类似物未能改变五名青春期前血清促性腺激素浓度患者的性早熟进程，这进一步证明，大多数患有McCune - Albright综合征女孩的性早熟机制与真性性早熟患者不同。
