Krutchkoff D J, Jones C R
J Oral Pathol. 1984 Oct;13(5):472-88. doi: 10.1111/j.1600-0714.1984.tb01448.x.
Eosinophilic granuloma has traditionally been designated as the least severe component of the inter-related triad of diseases, Histiocytosis X (Lichtenstein 1953, 1964). In 1969, Lieberman and his group questioned the use of this time-honored term and proposed instead that eosinophilic granuloma be regarded as a separate and distinct entity which could present either as a singular (unifocal) lesion or as a multifocal process. The term, "multifocal eosinophilic granuloma" was, thus, suggested as a replacement for the designation formerly known as Hand-Schuller-Christian Disease. The remaining component of Histiocytosis X termed Letterer-Siwe Disease was felt to be a totally separate disorder unrelated to eosinophilic granuloma and best classified as a relatively aggressive reticuloendothelial malignancy. In this presentation, we wish to report a case of multifocal eosinophilic granuloma which has run a very interesting course over a total of almost 10 years from the time of initial symptoms to the present. The more recent classification of Lieberman will be employed throughout this presentation. We will also propose the hypothesis that in this case, multifocal eosinophilic granuloma may represent a sequela of acquired immune deficiency perhaps initiated by T-cell viral infection. The possibility that, in a susceptible host, development of eosinophilic granuloma may be triggered by contact with environmental agents will also be discussed.
嗜酸性肉芽肿传统上被认为是组织细胞增多症X（Lichtenstein，1953年，1964年）这一相关疾病三联症中最不严重的组成部分。1969年，Lieberman及其团队对这个沿用已久的术语的使用提出质疑，转而提议将嗜酸性肉芽肿视为一个独立且独特的实体，它可以表现为单个（单灶性）病变或多灶性病变。因此，“多灶性嗜酸性肉芽肿”这一术语被建议用来取代以前称为汉-许-克病的名称。组织细胞增多症X的其余组成部分，即勒-雪病，被认为是一种与嗜酸性肉芽肿完全无关的独立疾病，最好归类为一种相对侵袭性的网状内皮恶性肿瘤。在本报告中，我们希望报告一例多灶性嗜酸性肉芽肿病例，从最初出现症状到现在，该病例在近10年的时间里呈现出非常有趣的病程。在本报告中将采用Lieberman的最新分类方法。我们还将提出一个假说，即在该病例中，多灶性嗜酸性肉芽肿可能是获得性免疫缺陷的后遗症，可能由T细胞病毒感染引发。我们还将讨论在易感宿主中，接触环境因素可能触发嗜酸性肉芽肿发展的可能性。
