Becker G M, McNulty W P
J Pathol. 1984 Aug;143(4):267-74. doi: 10.1002/path.1711430406.
Rhesus monkeys (Macaca mulatta) fed diets containing 1 or 3 mg/kg of 3,4,3',4'-tetrachlorobiphenyl (3,4-TCB), became moribund after 7-14 weeks. In the body of the stomach the mucosa was thick and cystic gastric glands penetrated the muscularis mucosae. The zymogenic and parietal cells were replaced by or converted into mucus-secreting cells. Autoradiographs of animals labelled with [3H]thymidine showed that in control monkeys gastric epithelial cell proliferation was limited to the isthmus and neck regions of the glands throughout the stomach. In the 3,4-TCB-fed animals most DNA synthesis also occurred in these regions, but [3H]thymidine labelled cells were also seen in the bases of the glands. The labelling indices were not elevated, and therefore the submucosal glands and cysts in this lesion may develop by a failure of the newly formed, downward migrating cells to differentiate and lose their proliferative capacity.
给恒河猴（猕猴）喂食含1或3毫克/千克3,4,3',4'-四氯联苯（3,4-TCB）的日粮，7至14周后濒死。胃体部黏膜增厚，囊性胃腺穿透黏膜肌层。胃酶原细胞和壁细胞被黏液分泌细胞取代或转化为黏液分泌细胞。用[3H]胸腺嘧啶核苷标记动物的放射自显影片显示，在对照猴中，胃上皮细胞增殖局限于整个胃腺的峡部和颈部区域。在喂食3,4-TCB的动物中，大多数DNA合成也发生在这些区域，但在腺底部也可见到[3H]胸腺嘧啶核苷标记的细胞。标记指数未升高，因此该病变中的黏膜下腺和囊肿可能是由于新形成的向下迁移细胞未能分化并失去增殖能力而形成的。
