Morozov A I, Rogachikova T A, Korshunov A I, Biriukov V A, Pinskaia L G
Med Radiol (Mosk). 1984 Sep;29(9):35-9.
Open-field gamma-beam therapy using grid filters was used for 53 patients with Stage III-III stomatopharyngeal tumors. Besides, to compare therapeutic efficacy the 2nd group was taken (52 persons with Stage III-IV) where chemotherapy was used simultaneously. Single and summary radiation doses did not lower. A chemotherapeutic agent dose was equal to 1/2 up to 2/3 of the standard one. Powerful substitution and hemostimulation therapy and a great variety of drugs were employed not to induce deep changes of hemopoiesis and immunosuppression. A single focal dose in gamma-beam therapy varied from 1.6 to 2.5 Gy, the summary dose from 55 to 70 Gy depending on the stage of disease and the histological structure of a tumor. The prescription of one or another chemotherapeutic agent was mainly determined by the morphological structure of a tumor.
53例III - III期口咽肿瘤患者采用使用格栅滤过器的开放野伽马射线治疗。此外,为比较治疗效果,选取了第二组(52例III - IV期患者),该组同时采用化疗。单次及总辐射剂量未降低。化疗药物剂量相当于标准剂量的1/2至2/3。采用了强力替代和促止血疗法以及多种药物,以避免引起造血和免疫抑制的深度变化。伽马射线治疗中的单次局部剂量为1.6至2.5 Gy,总剂量为55至70 Gy,具体取决于疾病分期和肿瘤的组织结构。选用何种化疗药物主要由肿瘤的形态结构决定。