Morozov A I, Korshunov A I, Biriukov V A, Pinskaia L G
Med Radiol (Mosk). 1986 Nov;31(11):35-9.
The paper is concerned with the results of radiation and multimodality (chemo- and radiotherapy) therapy of patients with malignant vulval tumors. All 112 patients had Stage III-IV disease. A single focal dose was 1.8-2.5 Gy, a summary dose varied from 65 to 100 Gy depending on growth type, tumor histological structure and other factors. Cyclophosphamide, thiotepa, methotrexate and 5-FU were used during simultaneous chemotherapy. Single and summary doses were administered according to an individual program. Drugs reducing local and general radiation reactions were widely used. A direct clinical cure and partial resorption were noted in 109 patients, no effect in 3. The use of various methods of gamma-beam therapy and chemoradiotherapy resulted in the 3-year survival in 51% and the 5-year survival in 18.7% of the patients.
本文关注恶性外阴肿瘤患者的放射治疗及多模式（化疗和放疗）治疗结果。所有112例患者均为Ⅲ - Ⅳ期疾病。单次局部剂量为1.8 - 2.5 Gy，总剂量根据生长类型、肿瘤组织学结构及其他因素在65至100 Gy之间变化。同步化疗期间使用了环磷酰胺、噻替派、甲氨蝶呤和5 - 氟尿嘧啶。单次剂量和总剂量根据个体化方案给药。广泛使用了减轻局部和全身放射反应的药物。109例患者出现直接临床治愈和部分吸收，3例无效。采用各种伽马射线治疗和放化疗方法后，患者的3年生存率为51%，5年生存率为18.7%。
