Lighton C, Marsden C A, Bennett G W, Minchin M, Green A R
Neuropharmacology. 1984 Aug;23(8):963-6. doi: 10.1016/0028-3908(84)90011-x.
The study investigated the effects of single and repeated electroconvulsive shock on levels and release of TRH in specific brain regions and thoracic and lumbar spinal cord. Whilst single electroconvulsive shock had no effect on TRH in any of the regions of the brain and spinal cord studied, repeated electroshock (5 shocks over 10 days and the rats killed 24 hr after the last shock) caused a significant decrease (-42 and -40% respectively) in levels of TRH in the nucleus accumbens and lumbar spinal cord. In the thoracic cord the level of TRH was also decreased after repeated electroshock but this did not reach significance. In contrast repeated electroshock had no significant effect on the content of TRH of the septal nuclei, hypothalamus, suprachiasmatic nucleus, or dorsal and medial raphe nuclei. Release of TRH was measured from slices prepared from nucleus accumbens and septal nuclei after repeated electroshock. A decrease in release was observed in nucleus accumbens with no effect in the septal nuclei. the results are discussed in relation to the possible interaction between dopaminergic and serotoninergic neurones and TRH in the antidepressant effects of electroconvulsive therapy.
该研究调查了单次和重复电惊厥休克对特定脑区以及胸段和腰段脊髓中促甲状腺激素释放激素（TRH）水平及释放的影响。虽然单次电惊厥休克对所研究的脑区和脊髓的任何区域中的TRH均无影响，但重复电休克（10天内进行5次休克，并在最后一次休克后24小时处死大鼠）导致伏隔核和腰段脊髓中TRH水平显著降低（分别降低42%和40%）。在胸段脊髓中，重复电休克后TRH水平也降低，但未达到显著水平。相比之下，重复电休克对隔核、下丘脑、视交叉上核或中缝背核和中缝内侧核的TRH含量无显著影响。在重复电休克后，从伏隔核和隔核制备的切片中测量TRH的释放。观察到伏隔核中TRH释放减少，而隔核中无影响。结合多巴胺能和5-羟色胺能神经元与TRH之间在电惊厥治疗抗抑郁作用中的可能相互作用对结果进行了讨论。
