Itaya P W, Thompson S A, Heidger P M
Prostate. 1984;5(5):513-30. doi: 10.1002/pros.2990050507.
Hypophysectomized rats were injected with prolactin and/or testosterone, and luteinizing hormone (LH) and prolactin and/or follicle-stimulating hormone (FSH). Tissue from the lateral prostate was processed for spectrophotometric determination of zinc and for electron microscopy. Changes in zinc concentration, epithelial height, and morphological characteristics were used to assess the effect of hormonal replacement on functional activity. Although testosterone administration resulted in full restoration of all parameters, there was no evidence of a synergistic effect of prolactin and testosterone. Prolactin alone decreased the zinc concentration and increased the epithelial height compared with control animals, and there was evidence of epithelial hyperplasia. Luteinizing hormone, alone or combined with prolactin or prolactin and FSH, resulted in a marked increase of epithelial height and restoration of morphological features found in intact animals; however, only a slight increase of zinc concentration over control values was elicited. Combined LH and FSH administration reduced epithelial height and zinc concentration compared with the other LH regimes, and there was evidence of cellular degeneration.
对垂体切除的大鼠注射催乳素和/或睾酮，以及促黄体生成素（LH）和催乳素和/或促卵泡激素（FSH）。取前列腺外侧组织进行锌的分光光度测定和电子显微镜检查。锌浓度、上皮高度和形态特征的变化用于评估激素替代对功能活性的影响。虽然给予睾酮可使所有参数完全恢复，但没有证据表明催乳素和睾酮有协同作用。与对照动物相比，单独给予催乳素可降低锌浓度并增加上皮高度，且有上皮增生的证据。单独的促黄体生成素，或与催乳素或催乳素和促卵泡激素联合使用，可导致上皮高度显著增加，并恢复完整动物中发现的形态特征；然而，与对照值相比，锌浓度仅略有增加。与其他促黄体生成素给药方案相比，联合给予促黄体生成素和促卵泡激素可降低上皮高度和锌浓度，且有细胞变性的证据。
