Lewis G P, Smith J R
Prostaglandins. 1984 Jul;28(1):29-41. doi: 10.1016/0090-6980(84)90111-4.
Electrical stimulation in the presence of ADP of arterioles of the hamster cheek pouch caused endothelial damage and white thrombus formation. The thrombus formation was inhibited by cyclo-oxygenase inhibitors aspirin and sulphinpyrazone and its thioether derivative G 25671. Thromboxane synthetase inhibitors N-(7-carboxyheptyl) imidazole and butylimidazole failed to inhibit thrombus formation, although in the same doses both compounds inhibited serum levels of thromboxane. These results indicate that thromboxane is not important in thrombus formation in the hamster, but that prostaglandin endoperoxides are more significant. However, it is possible that the inhibition of white thrombus formation by aspirin, sulphinpyrazone and G 25671 may be mediated by a different mechanism altogether.
在存在二磷酸腺苷（ADP）的情况下，对仓鼠颊囊小动脉进行电刺激会导致内皮损伤和白色血栓形成。血栓形成受到环氧化酶抑制剂阿司匹林、磺吡酮及其硫醚衍生物G 25671的抑制。血栓素合成酶抑制剂N-(7-羧基庚基)咪唑和丁基咪唑未能抑制血栓形成，尽管在相同剂量下这两种化合物均能抑制血栓素的血清水平。这些结果表明，血栓素在仓鼠血栓形成中并不重要，而前列腺素内过氧化物更为重要。然而，阿司匹林、磺吡酮和G 25671对白色血栓形成的抑制作用可能完全是由不同的机制介导的。
