Giacoia G P
South Med J. 1984 Oct;77(10):1261-3. doi: 10.1097/00007611-198410000-00014.
Concentrations of the rapid-turnover plasma proteins prealbumin and retinol-binding protein are measured in nonpregnant subjects to detect subclinical malnutrition. In this study, blood samples were taken from 30 normal pregnant women to establish normative data on the concentrations of these two plasma proteins during pregnancy. Twenty-five normal adults were used as controls. Total protein and albumin were concomitantly measured and, as expected, the concentration of both decreased during pregnancy. In contrast, plasma concentrations of prealbumin and retinol-binding protein remained unchanged. Two malnourished pregnant women had low levels of both prealbumin and retinol-binding protein, which reverted to normal once adequate caloric and protein intake was established. These findings suggest that prealbumin and retinol-binding protein measurements may be used during pregnancy to detect malnutrition and monitor the effect of dietary therapy.
在非妊娠受试者中测量快速周转血浆蛋白前白蛋白和视黄醇结合蛋白的浓度，以检测亚临床营养不良。在本研究中，采集了30名正常孕妇的血样，以建立这两种血浆蛋白在孕期浓度的规范数据。25名正常成年人作为对照。同时测量了总蛋白和白蛋白，正如预期的那样，二者浓度在孕期均下降。相比之下，前白蛋白和视黄醇结合蛋白的血浆浓度保持不变。两名营养不良的孕妇前白蛋白和视黄醇结合蛋白水平均较低，一旦建立了充足的热量和蛋白质摄入，其水平就恢复正常。这些发现表明，前白蛋白和视黄醇结合蛋白的测量可在孕期用于检测营养不良并监测饮食治疗的效果。
