Sachs E, Bernstein L H
Clin Chem. 1986 Feb;32(2):339-41.
We assessed age- and sex-related variation in those proteins commonly measured to evaluate protein catabolic losses in patients in acute care. We determined concentrations of iron and iron-binding capacity, transferrin, albumin, prealbumin, and retinol-binding protein in sera from 158 healthy blood donors and 48 hospitalized patients, then grouped the data according to age (by decade) and sex. There was no significant variation in either category. For the total nondiseased population the concentrations of three proteins (means SD, and range) were: transferrin, 2760, 510, 1740-3780 mg/L (population CV 18.5%); prealbumin, 296, 49, 200-390 mg/L (CV 16.6%); retinol-binding protein, 60, 127, 35-85 mg/L (CV 21.2%). Prealbumin and retinol-binding protein concentrations were highly correlated (r = 0.803). Because prealbumin can be easily monitored and its assay is subject to few interferences, we conclude that determination of prealbumin is suitable for assessing the existence and severity of nutritional metabolic deficits.
我们评估了在急性护理中用于评估患者蛋白质分解代谢损失的常见蛋白质的年龄和性别相关差异。我们测定了158名健康献血者和48名住院患者血清中铁、铁结合能力、转铁蛋白、白蛋白、前白蛋白和视黄醇结合蛋白的浓度，然后根据年龄（按十年分组）和性别对数据进行分组。在这两个类别中均无显著差异。对于总的非患病人群，三种蛋白质的浓度（均值±标准差和范围）分别为：转铁蛋白，2760、510、1740 - 3780 mg/L（群体变异系数18.5%）；前白蛋白，296、49、200 - 390 mg/L（变异系数16.6%）；视黄醇结合蛋白，60、12、35 - 85 mg/L（变异系数21.2%）。前白蛋白和视黄醇结合蛋白浓度高度相关（r = 0.803）。由于前白蛋白易于监测且其检测受干扰较少，我们得出结论，测定前白蛋白适用于评估营养代谢缺陷的存在和严重程度。
