Hope-Stone H F, Oliver R T, England H R, Blandy J P
Urology. 1984 Oct;24(4):315-20. doi: 10.1016/0090-4295(84)90199-7.
Treatment of a series of 194 patients with T3 (B2/C) tumors by radical radiotherapy, 5,000 to 5,500 rad in four weeks, produced a five-year survival of 40 per cent. Patients whose tumor completely disappeared after treatment (N = 97) had a five-year survival of 69 per cent. These results raise doubts about the necessity of performing elective cystectomy in patients who achieve complete response after radiotherapy, though the significantly better survival of partial responders who underwent salvage cystectomy emphasizes the need for an active policy of cystectomy once failure to respond completely to radiotherapy has been established and a need for techniques to give early indication of nonresponse to radiotherapy.
对194例T3（B2/C）期肿瘤患者进行根治性放疗，四周内给予5000至5500拉德，五年生存率为40%。治疗后肿瘤完全消失的患者（N = 97）五年生存率为69%。这些结果引发了对放疗后完全缓解的患者进行选择性膀胱切除术必要性的质疑，尽管接受挽救性膀胱切除术的部分缓解者生存率显著更高，这强调了一旦确定对放疗未完全反应，就需要积极采取膀胱切除术政策，以及需要有技术来早期提示对放疗无反应。
