Kallela K
Nord Vet Med. 1978 Mar;30(3):132-6.
The investigation concerns the interaction of plant estrogens, F-2 toxin, and natural estrogen (estradiol-benzoate) as causative factors of eostrogenic changes. Plant estrogens and F-2 toxin were applicated at three and estradiol-benzoate at two dosage levels. The estrogenic effect was studied by bioassay on immature rats taking uterine weight, uterine liquid and vaginal opening as criteria. When uterine weight is taken as a criterion, plant estrogens and F-2 toxin, no matter if they are administered alone or together, regularly increase the effect of estradiol-benzoate, but when uterine fluid is taken as a criterion they always decrease the effect of estradiol-benzoate. According to the present results it seems obvious, that the mode of action of estrogenic substances occurring in plants considerably differ from that of natural estrogens. Thus the mechanisms which cause disturbances may be different from those of natural estrogens.
该研究关注植物雌激素、F-2毒素和天然雌激素（苯甲酸雌二醇）作为雌激素变化致病因素的相互作用。植物雌激素和F-2毒素设置了三个剂量水平，苯甲酸雌二醇设置了两个剂量水平。通过以未成熟大鼠的子宫重量、子宫液和阴道开口为标准的生物测定法来研究雌激素效应。以子宫重量为标准时，植物雌激素和F-2毒素，无论单独给药还是联合给药，都会规律性地增强苯甲酸雌二醇的作用，但以子宫液为标准时，它们总是会减弱苯甲酸雌二醇的作用。根据目前的结果，植物中存在的雌激素物质的作用方式似乎明显不同于天然雌激素。因此，导致干扰的机制可能与天然雌激素的不同。
