氨曲南、头孢哌酮和阿米卡星单独或联合使用对大肠杆菌、肺炎克雷伯菌、粘质沙雷氏菌和铜绿假单胞菌的血清杀菌活性。
Serum bactericidal activity of aztreonam, cefoperazone, and amikacin, alone or in combination, against Escherichia coli, Klebsiella pneumoniae, Serratia marcescens, and Pseudomonas aeruginosa.
作者信息
Van Laethem Y, Husson M, Klastersky J
出版信息
Antimicrob Agents Chemother. 1984 Aug;26(2):224-7. doi: 10.1128/AAC.26.2.224.
Serum samples from volunteers receiving (per kilogram) 20 mg of aztreonam, 20 mg of cefoperazone, 7.5 mg of amikacin, 20 mg of cefoperazone plus 20 mg of aztreonam, or 20 mg of aztreonam plus 7.5 mg of amikacin were evaluated for bactericidal activity against Escherichia coli, Klebsiella pneumonia, Serratia marcescens, and Pseudomonas aeruginosa. Serum bactericidal activities were similar for aztreonam alone or in combination but were lower for amikacin and cefoperazone alone, especially against S. marcescens and P. aeruginosa. Killing studies, performed with serum samples diluted 1:8, demonstrated a high killing rate for aztreonam plus amikacin, especially against P. aeruginosa.
对接受（每千克）20毫克氨曲南、20毫克头孢哌酮、7.5毫克阿米卡星、20毫克头孢哌酮加20毫克氨曲南或20毫克氨曲南加7.5毫克阿米卡星的志愿者的血清样本，评估其对大肠杆菌、肺炎克雷伯菌、粘质沙雷氏菌和铜绿假单胞菌的杀菌活性。单独使用氨曲南或联合使用时血清杀菌活性相似，但单独使用阿米卡星和头孢哌酮时活性较低，尤其是对粘质沙雷氏菌和铜绿假单胞菌。用稀释1:8的血清样本进行的杀菌研究表明，氨曲南加阿米卡星的杀菌率很高，尤其是对铜绿假单胞菌。
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