Bonnet J, Colle J P, Lorient-Roudaut M F, Vergnes C, Haissaguerre M, Boisseau M R, Bricaud H
Arch Mal Coeur Vaiss. 1984 Sep;77(9):1033-9.
Forty patients (mean age = 56 +/- 17 years) hospitalized for proximal venous thrombosis of the lower limbs of over 7 days duration were treated with fibrinolytic drugs: streptokinase (SK) 28 cases, urokinase (UK) 12 cases. The efficacy of fibrinolytic therapy was assessed by phlebography before and 4.5 +/- 2 days after onset of treatment. A phlebographic score based on Marder's method was used to quantify the thrombosis. The repermeabilisation of venous branches was also noted. The results show an overall efficacy of fibrinolytic drugs: total lysis was observed in 6 patients and partial thrombolysis in 18 patients. The overall reduction of the phlebographic score was -2.8 +/- 3.9, and the rate of repermeabilisation of the femoral veins was over 50%. Streptokinase seemed to be the most effective drug. Better results were obtained when the thrombosis was treated early and was proximally situated, but good results were also observed in cases of total thrombosis with a floating thrombus. Effective fibrinolysis was observed in thromboses of up to 3 months duration. There was no correlation between biological efficacy and clinical symptoms. In conclusion, fibrinolytic drugs are partially effective in semi-recent or chronic venous thrombosis and their usefulness should not be overlooked, especially in cases of persistent thrombosis of the femoral veins.
40例因下肢近端静脉血栓形成住院超过7天的患者接受了溶栓药物治疗：链激酶（SK）治疗28例，尿激酶（UK）治疗12例。在治疗开始前和开始后4.5±2天通过静脉造影评估溶栓治疗的疗效。采用基于马德方法的静脉造影评分来量化血栓形成情况。还记录了静脉分支的再通情况。结果显示溶栓药物的总体疗效：6例患者出现完全溶解，18例患者出现部分溶栓。静脉造影评分的总体降低为-2.8±3.9，股静脉再通率超过50%。链激酶似乎是最有效的药物。当血栓形成早期且位于近端时，效果更佳，但在伴有漂浮血栓的完全血栓形成病例中也观察到了良好效果。在长达3个月的血栓形成中观察到了有效的纤溶作用。生物学疗效与临床症状之间无相关性。总之，溶栓药物在半近期或慢性静脉血栓形成中部分有效，其效用不应被忽视，尤其是在股静脉持续血栓形成的病例中。
