Wright B, Greig R, Poste G
Biochem Biophys Res Commun. 1984 Sep 17;123(2):710-5. doi: 10.1016/0006-291x(84)90287-0.
Cyclosporin (CsA)4, a fungal peptide used clinically for its immunosuppressive properties, was investigated for its ability to antagonize the activation of macrophages (PEM) to the tumoricidal state. The acquisition of tumoricidal properties by PEM challenged with macrophage activating factor (MAF) plus lipopolysaccharide (LPS) was inhibited in a dose-dependent fashion by CsA. Similarly, CsA antagonized activation of PEM exposed to the calcium ionophore, A23187. CsA also inhibited macrophage-mediated tumor cell cytolysis in a dose-dependent manner. These data indicate that in vitro, CsA can modulate directly the acquisition and expression of tumoricidal properties by PEM and suggests that the macrophage may be an important target cell for CsA in vivo.
环孢素（CsA）4是一种临床上因其免疫抑制特性而使用的真菌肽，研究了其拮抗巨噬细胞（PEM）激活至杀肿瘤状态的能力。用巨噬细胞激活因子（MAF）加脂多糖（LPS）刺激的PEM获得杀肿瘤特性受到CsA的剂量依赖性抑制。同样，CsA拮抗暴露于钙离子载体A23187的PEM的激活。CsA也以剂量依赖性方式抑制巨噬细胞介导的肿瘤细胞溶解。这些数据表明，在体外，CsA可直接调节PEM杀肿瘤特性的获得和表达，并提示巨噬细胞可能是CsA在体内的重要靶细胞。
