Naoi M, Yagi K
Biochem Int. 1984 Aug;9(2):267-72.
A series of glycolipids were examined to find a system capable of targeting liposomes into specific organs of rats. Sulfatide was found to be the best among the components of liposomes examined for delivering the entrapped enzyme, beta-galactosidase from Aspergillus oryzae, into the brain and liver; gangliosides, for the spleen; and sphingomyelin, for the lung. To introduce the enzyme into the liver, galactocerebroside was far better than glucocerebroside. These data suggest that the sugar residues of glycolipids function to target the liposomes into specific organs.
研究了一系列糖脂，以寻找一种能够将脂质体靶向运输到大鼠特定器官的系统。结果发现，在所检测的脂质体成分中，硫苷脂是将包封的来自米曲霉的β-半乳糖苷酶运输到脑和肝脏的最佳选择；神经节苷脂对脾脏效果最佳；鞘磷脂对肺效果最佳。为了将酶引入肝脏，半乳糖脑苷脂比葡萄糖脑苷脂效果要好得多。这些数据表明，糖脂的糖残基起到将脂质体靶向运输到特定器官的作用。
